After years of doing the remote control shuffle including some failed attempts at having one remote dominate the other, I picked up a Harmony 880.
To my astonishment, this thing actually works and I have put my tv remote, av remote, dvd remote, comcast remote, and apple tv remote all in a box on a shelf.
In my hand is one remote to rule them all.
Harmony has created an excellent web application to help you build up your remote around activites (e.g. watch tv, listen to the radio) and it has the nuance to handle even tricky stuff like getting apple tv on board and even including the 30 second skip for a comcast dvr.